Iridium catalyzed asymmetric hydrogenation of cyclic imines of benzodiazepinones and benzodiazepines.
نویسندگان
چکیده
Highly enantioselective Ir-catalyzed hydrogenation of seven-membered cyclic imines of benzodiazepinones and benzodiazepines was achieved with up to 96% ee. This method provides a direct access to synthesize a range of chiral cyclic amines existing in numerous important natural products and clinical drugs.
منابع مشابه
Iridium-catalyzed asymmetric hydrogenation of cyclic enamines.
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عنوان ژورنال:
- Organic letters
دوره 14 15 شماره
صفحات -
تاریخ انتشار 2012